Determination of the mutational signature of ionizing radiation using single-cell sequencing

Student

Felix Mathew

Directeur.e(s) de recherche

John Kildea

Start date

2019-09-01

Title of the research project

Determination of the mutational signature of ionizing radiation using single-cell sequencing

Description

This research project aims to examine the mutational signature of ionizing radiation using single-cell sequencing techniques.

The project is using human lymphoblastoid cells donated by the Ashkenazi trio that have a well characterized genome. The cells are irradiated and sequenced to determine the mutations that are induced as a result of the exposure to the ionizing radiation.

Through biostatistical analysis of the human genomic data thus obtained, we will be able to identify the mutational signature of ionizing radiation.

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