Title of the research project
Determination of the mutational signature of ionizing radiation using single-cell sequencing
Description
This research project aims to examine the mutational signature of ionizing radiation using single-cell sequencing techniques.
The project is using human lymphoblastoid cells donated by the Ashkenazi trio that have a well characterized genome. The cells are irradiated and sequenced to determine the mutations that are induced as a result of the exposure to the ionizing radiation.
Through biostatistical analysis of the human genomic data thus obtained, we will be able to identify the mutational signature of ionizing radiation.
