Student
Directeur.e(s) de recherche
John Kildea
Start date
Title of the research project
Determination of the mutational signature of ionizing radiation using single-cell sequencing
Description

This research project aims to examine the mutational signature of ionizing radiation using single-cell sequencing techniques.

The project is using human lymphoblastoid cells donated by the Ashkenazi trio that have a well characterized genome. The cells are irradiated and sequenced to determine the mutations that are induced as a result of the exposure to the ionizing radiation.

Through biostatistical analysis of the human genomic data thus obtained, we will be able to identify the mutational signature of ionizing radiation.
 

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Intraoperative analgesic treatment decisions based on the NOL index: contribution of a data-based approach to improve accuracy and relevance

Student member : Marzieh Ghiyasinasab

This research project is based on the analysis of massive data on the NOL index and other intraoperative clinical parameters used by anesthesiologists during surgery. These parameters help them make analgesic treatment decisions in a non-communicating patient under general anesthesia and in whom it is impossible to assess pain and analgesic needs by standard questionnaires performed on awake patients. 
First, the objective is to interpret the values of this index in relation to the decisions made by the clinician. 

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