Student
Directeur.e(s) de recherche
John Kildea
Start date
Title of the research project
Use of patient-reported outcomes and accumulated dose for accurate quantification of the dose-outcome relationship in hypofractionated prostate cancer radiotherapy
Description

This project is focused on determining if patient-reported outcomes are better correlated with actual dose delivered than with planned dose in prostate cancer patients receiving radiotherapy.

The project will use daily cone-beam CT images to calculate the daily and total radiation dose delivered to patients, and the Opal app to collect their patient-reported outcomes. 

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Radiotherapy treatments currently used in the clinical field are rarely modified. They generally consist of a global therapy of 50 grays, fractionated in five treatments of two grays every week for five weeks.
Thus, it could be worthwhile to develop a numeric tool, based on mathematical models found in the literature, in order to compare different types of treatment without having to test them on real tissues. Several parameters are known to alter the tissue response after irradiation including oxygen

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